A recent study reveals that people who come off popular GLP-1 drugs like Wegovy and Mounjaro can put back on lost weight much more quickly than those who stop conventional diet and exercise plans.
Research printed in a major health publication shows that while obese individuals often shed a large proportion of their total mass while undergoing treatment, the mass comes back at an estimated rate of nearly a kilo each month after stopping.
"Individuals buying such drugs need to be cognizant of the potential of quick rebound weight gain when the therapy is stopped," cautioned expert Dr. Susan Jebb.
This pace of regain suggests a reversion to pre-treatment weight in about one and a half years.
Weighing Therapies
The study, which reviewed dozens of studies involving thousands of patients, contrasted the outcomes of GLP-1 agonists with conventional dieting.
Researchers note that people who shed pounds through diet and exercise generally experience a more gradual weight regain—around 0.1 kg a month—once they finish.
The Reason for the Fast Regain
Nutrition scientists suggest the mechanism of the drugs accounts for the amplified regain.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which helps regulate appetite.
"Sustained high doses of the hormone concentrations several times higher than normal might result in the body to generate a reduced amount of its own natural GLP-1, and could reduce sensitivity to its effects," explained Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this medication means hunger is no longer kept in check, making excessive eating a significant risk."
A Chronic Condition?
The NHS advise the injections for individuals with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Many experts argue that, given the significant potential of weight regain, the treatment is often life-long.
This perspective is reinforced by drug manufacturers, who state that the results "underscore the persistent nature of obesity," akin to managing conditions like hypertension.
Patient Accounts
Users who have stopped the medication report a powerful return of cravings.
"It felt as if a switch flipping and you're instantly extremely hungry," said an individual.
This challenge is exacerbated if individuals have not developed lasting dietary or behavioural changes during therapy.
Significant Use
Figures show that a significant number of people in the UK have used these injections in the past year, with demand being substantial.
- Adoption is more common among females than males.
- The middle-aged age group shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than the NHS.
In conclusion, experts stress that while the jabs are effective agents for shedding pounds, they are not a magic cure and long-term success likely depends on combined lifestyle support.
